- On May 16, ISIS claimed responsibility for the attack on SAA members in Nawa city on 15th May
- On May 16, ISIS claimed responsibility for the attack on SDF vehicle west of Tabqah
- On May 16, ISIS claimed responsibility for the attack on SDF members south of Markadah
- On May 16, SDF with support of US coalition carried out a security operation in the Dhiban area
- On May 16, SAA artillery shelled positions of Turkish-backed forces north of Lattakia
- On May 16, Intra-clashes between Turkish-backed forces were reported in the Afrin city
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